Linkage analysis under locus heterogeneity: behaviour of the A-test in complex analyses.

@article{Janssen1997LinkageAU,
  title={Linkage analysis under locus heterogeneity: behaviour of the A-test in complex analyses.},
  author={Bart Janssen and D. R. Muhs K. R. Simmons R. B. Halley and Lodewijk A. Sandkuijl},
  journal={Human heredity},
  year={1997},
  volume={47 4},
  pages={223-33}
}
The admixture test (A-test) is a popular method for the analysis of linkage data when locus heterogeneity is suspected. It can be applied on pairwise linkage data, multipoint data and even for the simultaneous analysis of data from multiple dispersed candidate regions. However, very little is known about the conditions for the use of the method under these divergent circumstances. By performing analytical evaluations, we demonstrate that the A-test is inconsistent if there is a relationship… CONTINUE READING

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