Linkage analysis under "random" and "genetic" reduced penetrance.

  title={Linkage analysis under "random" and "genetic" reduced penetrance.},
  author={D. A. Greenberg and Susan E. Hodge},
  journal={Genetic epidemiology},
  volume={6 1},
We examined whether the results of linkage analysis are affected by the reasons for so-called "reduced penetrance". We simulated linkage data with random reduced penetrance and contrasted that with data that were simulated under inheritance controlled by two loci interacting epistatically. For the two-locus disease models, one of those loci was linked to the marker. All data, irrespective of how the data were simulated, were analyzed under the assumption of a single-locus genetic model with… CONTINUE READING