Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families.

@article{Farbrother2004LinkageAO,
  title={Linkage analysis of the genetic loci for high myopia on 18p, 12q, and 17q in 51 U.K. families.},
  author={Jane E Farbrother and George Kirov and Michael J Owen and Ricardo Pong-Wong and Chris S. Haley and Jeremy A Guggenheim},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 9},
  pages={2879-85}
}
PURPOSE To determine the extent to which high myopia in a cohort of 51 U.K. families can be attributed to currently identified genetic loci. METHODS The families comprised 245 subjects with phenotypic information and DNA available, of whom 170 were classified as affected. Subjects were genotyped for microsatellite markers spanning approximately 40cM regions on 18p (MYP2), 12q (MYP3) and 17q, together with markers flanking COL2A1, COL11A1, and FBN1. Two-point linkage analyses were performed… CONTINUE READING
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A new locus for autosomal dominant high myopia maps to chromosome 17q21-23 (abstract)

  • T Young, P Paluru, E Heon
  • Am J Hum Genet
  • 2001
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