Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study.

@article{Avery2004LinkageAO,
  title={Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study.},
  author={Christy L. Avery and Barry I. Freedman and Gerardo Heiss and Aldi Kraja and Treva Rice and Donna K Arnett and Michael B. Miller and James S. Pankow and Cora E. Lewis and Richard H. Myers and Steven C. Hunt and Laura Almasy and Kari E. North},
  journal={Diabetes},
  year={2004},
  volume={53 12},
  pages={3307-12}
}
Type 2 diabetes susceptibility is determined by multiple genetic and environmental factors. Genome-wide linkage scans have localized common regions, possibly harboring susceptibility genes on chromosomes 1, 2, 12, and 20. Variability in linkage findings underscores the probable genetic heterogeneity of type 2 diabetes. Thus, we conducted a genome scan of diabetes status using maximum likelihood methods that model affection status by a liability threshold model. Hypertensive sibships and their… CONTINUE READING

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