Linkage analysis of chromosome 4 in families with familial pancreatic cancer.

  title={Linkage analysis of chromosome 4 in families with familial pancreatic cancer.},
  author={Alison P Klein and Mariza de Andrade and Ralph H. Hruban and Melissa Bondy and Ann Grossbart Schwartz and Steven Gallinger and Henry T. Lynch and Sapna Syngal and Kari G. Rabe and Michael G. Goggins and G. M. van Petersen},
  journal={Cancer biology & therapy},
  volume={6 3},
BACKGROUND Approximately 10% of pancreatic ductal adenocarcinomas have a familial basis. While a small portion of this familial clustering can be explained by inherited mutations in known genes (BRCA2, p16/CDKN2A, PRSS1, and STK11), the genetic basis for the majority of this familial clustering remains unknown. In addition, a pancreatic cancer susceptibility locus has been reported to be linked to chromosome 4q32-34 in a single family having a high penetrance of early-onset pancreatic ductal… CONTINUE READING
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