Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease.

@article{Keating1992LinkageAA,
  title={Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease.},
  author={Michael Keating},
  journal={Circulation},
  year={1992},
  volume={85 6},
  pages={1973-86}
}
BACKGROUND Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the disorder. METHODS AND RESULTS Using this approach, we have identified linkage between a gene that causes the long QT syndrome and DNA markers on chromosome 11. CONCLUSIONS The… CONTINUE READING

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