Link between intraphagosomal biotin and rapid phagosomal escape in Francisella.

  title={Link between intraphagosomal biotin and rapid phagosomal escape in Francisella.},
  author={Brooke A Napier and Lena Meyer and James E Bina and Mark Andrew Miller and Anders Sj{\"o}stedt and David S Weiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 44},
Cytosolic bacterial pathogens require extensive metabolic adaptations within the host to replicate intracellularly and cause disease. In phagocytic cells such as macrophages, these pathogens must respond rapidly to nutrient limitation within the harsh environment of the phagosome. Many cytosolic pathogens escape the phagosome quickly (15-60 min) and thereby subvert this host defense, reaching the cytosol where they can replicate. Although a great deal of research has focused on strategies used… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
15 Extracted Citations
33 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 15 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…