Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi

@article{Porter2009LinkBA,
  title={Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi},
  author={Paul Porter and Sarat C Susarla and Sumanth Polikepahad and Yuping Qian and Jordan D Hampton and Attila Kiss and Swapnil V. Vaidya and Sanjiv Sur and Valentine Ongeri and Tianshu Yang and George L. Delclos and Stuart L Abramson and Farrah Kheradmand and David B Corry},
  journal={Mucosal Immunology},
  year={2009},
  volume={2},
  pages={504-517}
}
Active fungal proteinases are powerful allergens that induce experimental allergic lung disease strongly resembling atopic asthma, but the precise relationship between proteinases and asthma remains unknown. Here, we analyzed dust collected from the homes of asthmatic children for the presence and sources of active proteinases to further explore the relationship between active proteinases, atopy, and asthma. Active proteinases were present in all houses and many were derived from fungi… CONTINUE READING