Link between DNA damage and centriole disengagement/reduplication in untransformed human cells.

@article{Douthwright2014LinkBD,
  title={Link between DNA damage and centriole disengagement/reduplication in untransformed human cells.},
  author={Stephen Douthwright and Greenfield Sluder},
  journal={Journal of cellular physiology},
  year={2014},
  volume={229 10},
  pages={1427-36}
}
The radiation and radiomimetic drugs used to treat human tumors damage DNA in both cancer cells and normal proliferating cells. Centrosome amplification after DNA damage is well established for transformed cell types but is sparsely reported and not fully understood in untransformed cells. We characterize centriole behavior after DNA damage in synchronized untransformed human cells. One hour treatment of S phase cells with the radiomimetic drug, Doxorubicin, prolongs G2 by at least 72 h, though… CONTINUE READING

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