Linköping University Post Print CARD 8 p . C 10 X polymorphism is associated with inflammatory activity in early rheumatoid arthritis

@inproceedings{Kastbom2010LinkpingUP,
  title={Link{\"o}ping University Post Print CARD 8 p . C 10 X polymorphism is associated with inflammatory activity in early rheumatoid arthritis},
  author={Alf Kastbom and Martin Johansson and Deepti Raj Verma and Peter S{\"o}derkvist and Solbritt Rantap{\~a}{\~a}-Dahlqvist},
  year={2010}
}
Objectives: CARD8 and NLRP3 are constituents of the inflammasome, which regulates interleukin 1β production. We evaluated the influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity. Methods: CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and early RA patients from northern Sweden. The patients were monitored regularly during 2 years. The 28 joint disease activity score (DAS28) and its separate components were compared… CONTINUE READING

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