Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections.

  title={Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections.},
  author={Dennis Leroy Stevens and Daniel L. Herr and Harry W Lampiris and John Hunt and Donald H Batts and Barry Hafkin},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={34 11},
Linezolid, the first available member of a new antibiotic class, the oxazolidinones, is broadly active against gram-positive bacteria, including drug-resistant strains. In this randomized, open-label trial, hospitalized adults with known or suspected methicillin-resistant Staphylococcus aureus (MRSA) infections were treated with linezolid (600 mg twice daily; n=240) or vancomycin (1 g twice daily; n=220) for 7-28 days. S. aureus was isolated from 53% of patients; 93% of these isolates were MRSA… CONTINUE READING
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