Linezolid tissue penetration and serum activity against strains of methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in diabetic patients with foot infections.

@article{Stein2007LinezolidTP,
  title={Linezolid tissue penetration and serum activity against strains of methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in diabetic patients with foot infections.},
  author={Gary E. Stein and Sharon L Schooley and Charles A Peloquin and Anne E Missavage and Daniel H. Havlichek},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={60 4},
  pages={819-23}
}
OBJECTIVES Linezolid soft tissue penetration and serum antimicrobial activity were analysed in six patients with peripheral vascular disease and severe diabetic foot infections requiring surgical intervention. METHODS Blood draws (1, 3, 6, 9 and 12 h after initiation of a 1 h infusion) and a viable soft tissue sample at the site of infection were obtained in patients receiving linezolid (600 mg every 12 h) on the day of surgery. Concentrations of linezolid were determined by HPLC in both… CONTINUE READING

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