Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients.

@article{Hill2010LinezolidresistantSM,
  title={Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients.},
  author={Robert R. Hill and Angela M. Kearns and James Nash and Sarah E North and Rachel Pike and Timothy A Newson and Neil Woodford and Richard Calver and David Martin Livermore},
  journal={The Journal of antimicrobial chemotherapy},
  year={2010},
  volume={65 3},
  pages={442-5}
}
OBJECTIVES To describe the emergence of linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA) of sequence type (ST)36 lineage in two paediatric patients with cystic fibrosis, after long-term low-dose linezolid treatment. METHODS Two paediatric males with cystic fibrosis had sputum samples quantitatively cultured during hospitalization. After the isolation of MRSA from both patients, oral treatment with 300 mg linezolid twice daily was initiated for periods of 1-2 months… CONTINUE READING