Linezolid in vitro: mechanism and antibacterial spectrum.

  title={Linezolid in vitro: mechanism and antibacterial spectrum.},
  author={David Martin Livermore},
  journal={The Journal of antimicrobial chemotherapy},
  volume={51 Suppl 2},
Oxazolidinones are prominent among the new Gram-positive antimicrobial agents now becoming available. They were discovered by DuPont Pharmaceuticals in the late 1980s but linezolid, the first analogue suitable for development, was found only when the family was re-examined by Pharmacia in the 1990s. Oxazolidinones bind to the 50S subunit of the prokaryotic ribosome, preventing formation of the initiation complex for protein synthesis. This is a novel mode of action; other protein synthesis… CONTINUE READING
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Antianaerobic activity of RBx 7644, a new oxazolidinone, compared with ten other agents

  • L. Ednie, M. Jacobs, A. Rattan, P. Appelbaum
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