Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

@article{Narita2007LinezolidassociatedPA,
  title={Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.},
  author={Masashi Narita and Brian T. Tsuji and Victor L. Yu},
  journal={Pharmacotherapy},
  year={2007},
  volume={27 8},
  pages={1189-97}
}
Linezolid is an oxazolidinone antibacterial agent indicated for serious gram-positive infections. Only minor adverse effects were seen in phase III trials. However, more serious adverse effects were reported after commercial release, including cases of lactic acidosis, peripheral and optic neuropathy, and serotonin syndrome. Peripheral and optic neuropathy was usually seen after several months of linezolid therapy (median 5 mo), lactic acidosis after several weeks (median 6 wks), and serotonin… CONTINUE READING

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