Linezolid as treatment for pulmonary Mycobacterium avium disease.

  title={Linezolid as treatment for pulmonary Mycobacterium avium disease.},
  author={Devyani Deshpande and Shashikant Srivastava and Jotam G. Pasipanodya and Tawanda Gumbo},
  journal={The Journal of antimicrobial chemotherapy},
  volume={72 suppl_2},
Objectives To identify the pharmacokinetic/pharmacodynamic parameters and exposures of linezolid in the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Methods Human-derived monocytes infected with MAC were inoculated into hollow-fibre systems for dose-effect and dose-scheduling studies. We mimicked linezolid concentration-time profiles achieved in adult human lungs treated for 28 days. Sampling to confirm that the intended linezolid pharmacokinetics had been achieved, and… CONTINUE READING