Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.

  title={Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.},
  author={Philippe Cottagnoud and Cynthia M Gerber and F. Acosta and Marianne Cottagnoud and Klaus A. Neftel and Martin George T{\"a}uber},
  journal={The Journal of antimicrobial chemotherapy},
  volume={46 6},
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally… CONTINUE READING


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