Linearization of ancestral multichromosomal genomes

  title={Linearization of ancestral multichromosomal genomes},
  author={J{\'a}n Manuch and Murray Patterson and Roland Wittler and C{\'e}dric Chauve and Eric Tannier},
  booktitle={BMC Bioinformatics},
Recovering the structure of ancestral genomes can be formalized in terms of properties of binary matrices such as the Consecutive-Ones Property (C1P). The Linearization Problem asks to extract, from a given binary matrix, a maximum weight subset of rows that satisfies such a property. This problem is in general intractable, and in particular if the ancestral genome is expected to contain only linear chromosomes or a unique circular chromosome. In the present work, we consider a relaxation of… CONTINUE READING