Linear ubiquitination: a newly discovered regulator of cell signalling.

@article{Rieser2013LinearUA,
  title={Linear ubiquitination: a newly discovered regulator of cell signalling.},
  author={Eva Rieser and Stefanie M. Cordier and Henning Walczak},
  journal={Trends in biochemical sciences},
  year={2013},
  volume={38 2},
  pages={
          94-102
        }
}
Ubiquitination is a post-translational modification that creates versatility in cell signalling, in part because eight biochemically different inter-ubiquitin linkages can be formed through the seven internal lysine residues of ubiquitin or its amino-terminal methionine. The latter, referred to as linear or M1 linkage, is created by the linear ubiquitin chain assembly complex (LUBAC). Previously, K63 linkages were thought to be exclusively responsible for ubiquitin-mediated nondegradative… CONTINUE READING
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