Linear programming optimization and a double statistical filter for protein threading protocols.

@article{Meller2001LinearPO,
  title={Linear programming optimization and a double statistical filter for protein threading protocols.},
  author={Jaroslaw Meller and Ron Elber},
  journal={Proteins},
  year={2001},
  volume={45 3},
  pages={241-61}
}
The design of scoring functions (or potentials) for threading, differentiating native-like from non-native structures with a limited computational cost, is an active field of research. We revisit two widely used families of threading potentials: the pairwise and profile models. To design optimal scoring functions we use linear programming (LP). The LP protocol makes it possible to measure the difficulty of a particular training set in conjunction with a specific form of the scoring function… CONTINUE READING

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