Linear plasmids and chromosomes in bacteria

@article{Hinnebusch1993LinearPA,
  title={Linear plasmids and chromosomes in bacteria},
  author={Joseph Hinnebusch and Kit Tilly},
  journal={Molecular Microbiology},
  year={1993},
  volume={10}
}
Linear plasmids and chromosomes were unknown in prokaryotes until recently but have now been found in spirochaetes, Gram‐positive bacteria, and Gram‐negative bacteria. Two structural types of bacterial linear DNA have been characterized. Linear plasmids of the spirochaete Borrelia have a covalently closed hairpin loop at each end and linear plasmids of the Gram‐positive filamentous Streptomyces have a covalently attached protein at each end. Replicons with similar structures are more frequent… Expand
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The linear replicons of Borrelia and Streptomyces, despite their identical topology, appear to be highly diversified in their structures and modes of replication. Expand
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This study has confirmed the presence of such linear plasmids in mycobacteria, including M. avium, and demonstrated that the ends of these replicons are covalently bound with protein(s), suggesting an invertron-like structure. Expand
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Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres
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These linear chromosomes have covalently closed hairpin structures at their termini that are similar but not identical to those reported for linear plasmids carried by these organisms, suggesting that there has been historical exchange of genetic information between the linear Plasmids and the right end of the linear chromosome. Expand
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While the rapid evolution of bacteria due to horizontal plasmid transfer has historically dominated this research field, increasing attention is being paid to the (co)evolutionary interactions that shape the long-term population dynamics of bacteria and plasmids. Expand
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The first purification and definitive identification of a telomere resolvase has been reported for phage N15, which is the prototype for a new class of DNA enzyme that performs a unique reaction. Expand
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