Linear models and empirical bayes methods for assessing differential expression in microarray experiments.

@article{Smyth2004LinearMA,
  title={Linear models and empirical bayes methods for assessing differential expression in microarray experiments.},
  author={Gordon K Smyth},
  journal={Statistical applications in genetics and molecular biology},
  year={2004},
  volume={3},
  pages={Article3}
}
  • Gordon K Smyth
  • Published 2004 in
    Statistical applications in genetics and…
The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior odds of differential expression in a replicated two-color experiment using a simple hierarchical parametric model. The purpose of this paper is to develop the hierarchical model of Lonnstedt and Speed (2002) into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples… CONTINUE READING
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