Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium

  title={Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium},
  author={B. Groner and L. Hennighausen},
  journal={Breast Cancer Research},
  pages={149 - 153}
  • B. Groner, L. Hennighausen
  • Published 2000
  • Biology, Medicine
  • Breast Cancer Research
  • The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and involution. Signaling pathways have been identified that connect the hormonal stimuli with the transcription of genes responsible for the determination of the cellular fate. The kinetics of induction and deinduction have suggested that cytokine-activated Stat proteins play a crucial role. Stat5… CONTINUE READING
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