Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium

@article{Groner2000LinearAC,
  title={Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium},
  author={Bernd Groner and Lothar Hennighausen},
  journal={Breast Cancer Research},
  year={2000},
  volume={2},
  pages={149 - 153}
}
The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and involution. Signaling pathways have been identified that connect the hormonal stimuli with the transcription of genes responsible for the determination of the cellular fate. The kinetics of induction and deinduction have suggested that cytokine-activated Stat proteins play a crucial role. Stat5… 
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TLDR
Functional observations made in cultured mammary epithelial cells and in gene knockout mice identify Stat5 as a multifunctional regulator of mammary cell proliferation, milk protein gene expression, and postlactational apoptosis.
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Oncostatin M Induces Growth Arrest of Mammary Epithelium via a CCAAT / enhancer-binding Protein-dependent Pathway 1
TLDR
It is demonstrated that OSM induces up-regulation of C/EBP via a Stat3dependent pathway in mammary epithelial cells and that the growth inhibition induced by OSM depends on the presence of C-EBP, which is inversely correlated with the histological grade of malignancy.
STAT 3 Activity and Function in Cancer : Modulation by STAT 5 and miR-146 b
TLDR
Understanding the subtleties of STAT3 signaling in cancer pathogenesis will allow the development of more rational molecular approaches to cancer therapy, and will gain greater insight into the consequence ofSTAT3 activation in the biology of human cancers.
STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
TLDR
Understanding the subtleties of STAT3 signaling in cancer pathogenesis will allow the development of more rational molecular approaches to cancer therapy, and will gain greater insight into the consequence ofSTAT3 activation in the biology of human cancers.
Conditional Deletion of Shp2 in the Mammary Gland Leads to Impaired Lobulo-alveolar Outgrowth and Attenuated Stat5 Activation*
TLDR
This is the first demonstration that Shp2 manipulates Stat5 and Stat3 activities reciprocally in mammary epithelial cells, providing novel insight into the complex mechanisms for regulation of various Stat family members by a cytoplasmic tyrosine phosphatase.
Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.
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