Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons

@article{Cash1999LinearSO,
  title={Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons},
  author={Sydney S. Cash and Rafael Yuste},
  journal={Neuron},
  year={1999},
  volume={22},
  pages={383-394}
}

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References

SHOWING 1-10 OF 58 REFERENCES

Input Summation by Cultured Pyramidal Neurons Is Linear and Position-Independent

Dendritic morphology does not interfere with this linearity, which may be essential for particular neuronal computations, and recent results indicate that dendrites have voltage-sensitive conductances and are not passive cables.

Amplification and linearization of distal synaptic input to cortical pyramidal cells.

Computer simulations were used to study the effect of voltage-dependent calcium and potassium conductances in the apical dendritic tree of a pyramidal cell on the synaptic efficacy of apical synaptic input and derived activation curves that allowed explicit characterization of the input-output relationship of the entire neuron.

Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing.

Analog AND-NOT operations realized by satisfying critical conditions in the case of a delta-like ganglion cell of the cat retina may underlie direction selectivity in ganglions.

Active properties of neuronal dendrites.

The results support previous notions about the dendritic propagation of action potentials and also indicate which types of voltage-gated sodium and calcium channels are expressed and functionally active in dendrites.

Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites

How effectively synaptic and regenerative potentials propagate within neurons depends critically on the membrane properties and intracellular resistivity of the dendritic tree. These properties

K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons

There turns out to be a very high density of transient A-type potassium ion channels in dendrites of hippocampal CA1 pyramidal neurons, which act to prevent large, rapid dendritic depolarizations, thereby regulating orthograde and retrograde propagation of dendrite potentials.

Activity-dependent scaling of quantal amplitude in neocortical neurons

A new form of synaptic plasticity is described that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity, and may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs.

Linearity of summation of synaptic potentials underlying direction selectivity in simple cells of the cat visual cortex.

Intracellular recordings from simple cells of the cat visual cortex were used to test linear models for the generation of selectivity for the direction of visual motion and the fluctuations in membrane potential evoked by moving stimuli were accurately predicted by the linear summation of responses to stationary stimuli.

Direction selectivity of synaptic potentials in simple cells of the cat visual cortex.

A linear model of direction selectivity was used to analyze the synaptic potentials evoked by stationary sine-wave gratings and a more constrained test of linearity of synaptic summation based on principal component analysis was applied to the responses of direction-selective cells to stationary gratings, confirming that the summation in these cells is highly linear.
...