Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons

  title={Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons},
  author={S. Cash and R. Yuste},
  • S. Cash, R. Yuste
  • Published 1999
  • Medicine, Biology
  • Neuron
  • A fundamental problem in neurobiology is understanding the arithmetic that dendrites use to integrate inputs. The impact of dendritic morphology and active conductances on input summation is still unknown. To study this, we use glutamate iontophoresis and synaptic stimulation to position pairs of excitatory inputs throughout the apical, oblique, and basal dendrites of CA1 pyramidal neurons in rat hippocampal slices. Under a variety of stimulation regimes, we find a linear summation of most… CONTINUE READING
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