Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.

@article{Humphries2013LineageTR,
  title={Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.},
  author={Adam Humphries and Biancastella Cereser and Laura J Gay and Daniel S J Miller and Bibek Das and Alice Gutteridge and George Elia and Emma Nye and Rosemary Jeffery and Richard Poulsom and Marco R. Novelli and Manuel Rodriguez-Justo and Stuart Ac McDonald and Nicholas Anthony Wright and Trevor A Graham},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 27},
  pages={
          E2490-9
        }
}
The genetic and morphological development of colorectal cancer is a paradigm for tumorigenesis. However, the dynamics of clonal evolution underpinning carcinogenesis remain poorly understood. Here we identify multipotential stem cells within human colorectal adenomas and use methylation patterns of nonexpressed genes to characterize clonal evolution. Numerous individual crypts from six colonic adenomas and a hyperplastic polyp were microdissected and characterized for genetic lesions. Clones… CONTINUE READING
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Use of methylation patterns to determine expansion of stem cell clones in human colon tissue

  • TA Graham
  • Gastroenterology 140(4):1241-1250.e1249
  • 2011
Highly Influential
5 Excerpts

Breast Cancer Working Group of the International Cancer Genome Consortium (2012) The life history of 21 breast cancers

  • S Nik-Zainal
  • Cell
  • 2012
1 Excerpt