Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis.

@article{Chu2011LineageTD,
  title={Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis.},
  author={A Chu and Rosalyn D{\'i}az and J Hui and Kilangsungla Yanger and Yiwei Zong and Gianfranco D Alpini and Ben Z. Stanger and Rebecca G Wells},
  journal={Hepatology},
  year={2011},
  volume={53 5},
  pages={1685-95}
}
UNLABELLED Whether or not cholangiocytes or their hepatic progenitors undergo an epithelial-to-mesenchymal transition (EMT) to become matrix-producing myofibroblasts during biliary fibrosis is a significant ongoing controversy. To assess whether EMT is active during biliary fibrosis, we used Alfp-Cre × Rosa26-YFP mice, in which the epithelial cells of the liver (hepatocytes, cholangiocytes, and their bipotential progenitors) are heritably labeled at high efficiency with yellow fluorescent… CONTINUE READING
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