Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling.

  title={Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling.},
  author={Stephan Grouls and Diana Margarita Iglesias and Nicolas Wentzensen and Marcus M{\"o}ller and Maxime Bouchard and Rolf Kemler and Paul Goodyer and Felix K. Niggli and Hermann-Josef Gr{\"o}ne and Wilhelm Kriz and Robert Koesters},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={23 1},
β-Catenin/Wnt signaling is essential during early inductive stages of kidney development, but its role during postinductive stages of nephron development and maturation is not well understood. In this study, we used Pax8Cre mice to target β-catenin deficiency to renal epithelial cells at the late S-shaped body stage and the developing collecting ducts. The conditional β-catenin knockout mice formed abnormal kidneys and had reduced renal function. The kidneys were hypoplastic with a thin cortex… CONTINUE READING
23 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…