Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications.

@article{Glauche2007LineageSO,
  title={Lineage specification of hematopoietic stem cells: mathematical modeling and biological implications.},
  author={Ingmar Glauche and Michael Cross and Markus Loeffler and Ingo Roeder},
  journal={Stem cells},
  year={2007},
  volume={25 7},
  pages={1791-9}
}
  • Ingmar Glauche, Michael Cross, +1 author Ingo Roeder
  • Published 2007 in Stem cells
Lineage specification of hematopoietic stem cells is considered a progressive restriction in lineage potential. This view is consistent with observations that differentiation and lineage specification is preceded by a low-level coexpression of lineage specific, potentially antagonistic genes in early progenitor cells. This coexistence, commonly referred to as priming, disappears in the course of differentiation when certain lineage-restricted genes are upregulated while others are downregulated… CONTINUE READING

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Towards an understanding of lineage specification in hematopoietic stem cells : A mathematical model for the interaction of transcription factors GATA1 and PU . 1

  • Glauche Roeder
  • 2006

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