Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases.

@article{Esyunina2016LineagespecificVI,
  title={Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases.},
  author={Daria Esyunina and Matti Turtola and Danil Pupov and Irina Bass and Saulius Klima{\vs}auskas and Georgiy A Belogurov and Andrey Kulbachinskiy},
  journal={Nucleic acids research},
  year={2016},
  volume={44 3},
  pages={
          1298-308
        }
}
RNA cleavage by bacterial RNA polymerase (RNAP) has been implicated in transcriptional proofreading and reactivation of arrested transcription elongation complexes but its molecular mechanism is less understood than the mechanism of nucleotide addition, despite both reactions taking place in the same active site. RNAP from the radioresistant bacterium Deinococcus radiodurans is characterized by highly efficient intrinsic RNA cleavage in comparison with Escherichia coli RNAP. We find that the… CONTINUE READING

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