Lineage-specific responses to reduced embryonic Pax3 expression levels.

  title={Lineage-specific responses to reduced embryonic Pax3 expression levels.},
  author={Hong-ming Zhou and Jian Wang and Rhonda H. Rogers and Simon J. Conway},
  journal={Developmental biology},
  volume={315 2},
Pax3 is an essential paired- and homeodomain-containing transcription factor that is necessary for closure of the neural tube, and morphogenesis of the migratory neural crest and myoblast lineages. Homozygous loss-of-function mutation results in mid-gestational lethality with defects in myogenesis, neural tube closure and neural crest-derived lineages including melanocytes, Schwann cells and insufficient mesenchymal cells to septate the cardiac outflow tract. To address the function of Pax3 in… CONTINUE READING

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