Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell types.

@article{Srensen2010LineagespecificPD,
  title={Lineage-specific promoter DNA methylation patterns segregate adult progenitor cell types.},
  author={Anita L. S\orensen and Sanna Timoskainen and Franklin D. West and Kristin Vekterud and Andrew C. Boquest and Lars Ahrlund-Richter and Steve L. Stice and Philippe Collas},
  journal={Stem cells and development},
  year={2010},
  volume={19 8},
  pages={1257-66}
}
Mesenchymal stem cells (MSCs) can differentiate into multiple mesodermal cell types in vitro; however, their differentiation capacity is influenced by their tissue of origin. To what extent epigenetic information on promoters of lineage-specification genes in human progenitors influences transcriptional activation and differentiation potential remains unclear. We produced bisulfite sequencing maps of DNA methylation in adipogenic, myogenic, and endothelial promoters in relation to gene… CONTINUE READING