Lineage-specific functions of TET1 in the postimplantation mouse embryo

  title={Lineage-specific functions of TET1 in the postimplantation mouse embryo},
  author={Rita Khoueiry and Abhishek Sohni and Bernard Thienpont and Xinlong Luo and Joris Vande Velde and Michela Bartoccetti and Bram Boeckx and An Zwijsen and Anjana Rao and Diether Lambrechts and Kian Peng Koh},
  journal={Nature Genetics},
The mammalian TET enzymes catalyze DNA demethylation. While they have been intensely studied as major epigenetic regulators, little is known about their physiological roles and the extent of functional redundancy following embryo implantation. Here we define non-redundant roles for TET1 at an early postimplantation stage of the mouse embryo, when its paralogs Tet2 and Tet3 are not detectably expressed. TET1 regulates numerous genes defining differentiation programs in the epiblast and… CONTINUE READING
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