Lineage specific differentiation of pluripotent cells in vitro: a role for extraembryonic cell types.

@article{Rathjen2001LineageSD,
  title={Lineage specific differentiation of pluripotent cells in vitro: a role for extraembryonic cell types.},
  author={Joy Rathjen and Stephanie Schartel Dunn and Michael D Bettess and Peter David Rathjen},
  journal={Reproduction, fertility, and development},
  year={2001},
  volume={13 1},
  pages={15-22}
}
The controlled differentiation of pluripotent cells will be a prerequisite for many cell therapies. We have previously reported homogeneous conversion of embryonic stem (ES) cells in vitro to early primitive ectoderm-like (EPL) cells, equivalent to early primitive ectoderm, an obligatory differentiation intermediate between ES cells and somatic cell populations. Early primitive ectoderm-like cells differentiated within aggregates form mesodermal lineages at the expense of ectoderm. In this work… CONTINUE READING