Lineage relationship of prostate cancer cell types based on gene expression

  title={Lineage relationship of prostate cancer cell types based on gene expression},
  author={Laura E Pascal and Ricardo Zorzetto V{\^e}ncio and Robert L. Vessella and Carol B Ware and Eneida Franco V{\^e}ncio and Gareth S. Denyer and Alvin Y. Liu},
  booktitle={BMC Medical Genomics},
Prostate tumor heterogeneity is a major factor in disease management. Heterogeneity could be due to multiple cancer cell types with distinct gene expression. Of clinical importance is the so-called cancer stem cell type. Cell type-specific transcriptomes are used to examine lineage relationship among cancer cell types and their expression similarity to normal cell types including stem/progenitor cells. Transcriptomes were determined by Affymetrix DNA array analysis for the following cell types… CONTINUE READING
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