Lineage relationship of CD8+ T cell subsets is revealed by progressive changes in the epigenetic landscape


To better elucidate epigenetic mechanisms that correlate with the dynamic gene expression program observed upon T-cell differentiation, we investigated the genomic landscape of histone modifications in naive and memory CD8+ T cells. Using a ChIP-Seq approach coupled with global gene expression profiling, we generated genome-wide histone H3 lysine 4 (H3K4me3… (More)
DOI: 10.1038/cmi.2015.32



Citations per Year

Citation Velocity: 26

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