Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract

@article{Cheng2005LineageIO,
  title={Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract},
  author={W. Cheng and J. Liu and H. Yoshida and D. Rosen and H. Naora},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={531-537}
}
  • W. Cheng, J. Liu, +2 authors H. Naora
  • Published 2005
  • Biology, Medicine
  • Nature Medicine
  • Although epithelial ovarian cancers (EOCs) have been thought to arise from the simple epithelium lining the ovarian surface or inclusion cysts, the major subtypes of EOCs show morphologic features that resemble those of the müllerian duct–derived epithelia of the reproductive tract. We found that HOX genes, which normally regulate müllerian duct differentiation, are not expressed in normal ovarian surface epithelium (OSE), but are expressed in different EOC subtypes according to the pattern of… CONTINUE READING
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