Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.

@article{Kane2015LineageSpecificVH,
  title={Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.},
  author={Joshua R Kane and David J. Stanley and Judd F. Hultquist and Jeffrey R. Johnson and Nicole Mietrach and Jennifer M Binning and Stef{\'a}n Ragnar J{\'o}nsson and Sarah Barelier and Billy W. Newton and Tasha L Johnson and Kathleen E Franks-Skiba and Ming Li and William L. Brown and H{\"o}rður Ingi Gunnarsson and Adalbjorg Adalbjornsd{\'o}ttir and James S. Fraser and Reuben S Harris and Valgerður Andr{\'e}sd{\'o}ttir and John D Gross and Nevan J. Krogan},
  journal={Cell reports},
  year={2015},
  volume={11 8},
  pages={1236-50}
}
HIV-1 encodes the accessory protein Vif, which hijacks a host Cullin-RING ubiquitin ligase (CRL) complex as well as the non-canonical cofactor CBFβ, to antagonize APOBEC3 antiviral proteins. Non-canonical cofactor recruitment to CRL complexes by viral factors, to date, has only been attributed to HIV-1 Vif. To further study this phenomenon, we employed a comparative approach combining proteomic, biochemical, structural, and virological techniques to investigate Vif complexes across the… CONTINUE READING
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