Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

@inproceedings{Boroviak2015LineageSpecificPD,
  title={Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis},
  author={Thorsten Boroviak and Remco Loos and Patrick D Lombard and Junko Okahara and R{\"u}diger Behr and Erika Sasaki and Jennifer Nichols and Austin G. Smith and Paul Bertone},
  booktitle={Developmental cell},
  year={2015}
}
Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we determine transcriptome dynamics of mouse development from the eight-cell stage to postimplantation using lineage-specific RNA sequencing. This method combines high sensitivity and reporter-based fate assignment to acquire the full spectrum of gene expression from discrete embryonic cell types. We define expression modules indicative of developmental state and temporal regulatory patterns marking the establishment… CONTINUE READING
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