Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution

  title={Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution},
  author={Andrew Fortna and Young Cheon Kim and Erik J Maclaren and Kriste E Marshall and Gretchen Hahn and Lynne Meltesen and Matthew D Brenton and Raquel L Hink and Sonya Burgers and Tina Hernandez-Boussard and Anis Karimpour-Fard and Deborah A Glueck and Loris McGavran and Rebecca Rialon Berry and Jonathan R. Pollack and James M. Sikela},
  journal={PLoS Biology},
  pages={1005 - 1017}
Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions among several hominoid lineages. Interspecies cDNA array-based comparative genomic hybridization was used to individually compare copy number variation for 39,711 cDNAs, representing 29,619 human… CONTINUE READING
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