Lineage-Specific Expansions of Retroviral Insertions within the Genomes of African Great Apes but Not Humans and Orangutans

  title={Lineage-Specific Expansions of Retroviral Insertions within the Genomes of African Great Apes but Not Humans and Orangutans},
  author={Chris T Yohn and Zhaoshi Jiang and Sean D. McGrath and Karen E. Hayden and Philipp Khaitovich and Matthew E. Johnson and Marla Y Eichler and John D. McPherson and Shaying Zhao and Svante P{\"a}{\"a}bo and Evan E. Eichler},
  journal={PLoS Biology},
  pages={465 - 535}
Retroviral infections of the germline have the potential to episodically alter gene function and genome structure during the course of evolution. Horizontal transmissions between species have been proposed, but little evidence exists for such events in the human/great ape lineage of evolution. Based on analysis of finished BAC chimpanzee genome sequence, we characterize a retroviral element (Pan troglodytes endogenous retrovirus 1 [PTERV1]) that has become integrated in the germline of African… CONTINUE READING


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