Lineage, fate, and fate potential of NG2-glia.

  title={Lineage, fate, and fate potential of NG2-glia.},
  author={Akiko Nishiyama and Linda Boshans and Christopher M Gonçalves and Jill L. Wegrzyn and Kiran D Patel},
  journal={Brain research},
  volume={1638 Pt B},
NG2 cells represent a fourth major glial cell population in the mammalian central nervous system (CNS). They arise from discrete germinal zones in mid-gestation embryos and expand to occupy the entire CNS parenchyma. Genetic fate mapping studies have shown that oligodendrocytes and a subpopulation of ventral protoplasmic astrocytes arise from NG2 cells. This review describes recent findings on the fate and fate potential of NG2 cells under physiological and pathological conditions. We discuss… CONTINUE READING