• DOI:10.1117/1.JBO.23.10.106007
• Corpus ID: 53023955

Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

@article{Dubois2018LinefieldCO,
  title={Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors},
  author={Arnaud Dubois and Olivier Levecq and Hicham Azimani and David Siret and Ana{\"i}s Barut and Mariano Suppa and V{\'e}ronique del Marmol and Josep Malvehy and Elisa Cinotti and Pietro Rubegni and Jean Luc Perrot},
  journal={Journal of Biomedical Optics},
  year={2018},
  volume={23}
}

• A. Dubois, Olivier Levecq, +8 authors J. Perrot
• Published 1 October 2018
• Physics
• Journal of Biomedical Optics

Abstract. An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo. LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10  frame  /  s. With an isotropic spatial resolution of ∼1  μm, the LC-OCT images reveal a comprehensive structural mapping of skin at the cellular level down to a depth of ∼500  μm. LC-OCT has been applied to the imaging of various skin lesions, in vivo, including carcinomas and melanomas. LC-OCT images are found to strongly correlate with conventional histopathological images. The use of LC-OCT as an adjunct tool in medical practice could significantly improve clinical diagnostic accuracy while reducing the number of biopsies of benign lesions.