Lindane cytotoxicity in cultured neocortical neurons is ameliorated by GABA and flunitrazepam

@article{Pomes1994LindaneCI,
  title={Lindane cytotoxicity in cultured neocortical neurons is ameliorated by GABA and flunitrazepam},
  author={A. Pomes and A. Frandsen and C. Su{\~n}ol and C. Sanfeliu and E. Rodrı́guez-Farr{\'e} and A. Schousboe},
  journal={Journal of Neuroscience Research},
  year={1994},
  volume={39}
}
  • A. Pomes, A. Frandsen, +3 authors A. Schousboe
  • Published 1994
  • Biology, Medicine
  • Journal of Neuroscience Research
  • The effect of lindane (γ‐hexachlorocyclohexane) on [35S]t‐butylbicyclophosphorothionate ([35S]TBPS) binding and GABA‐stimulated 36Cl− influx was investigated in cultured cerebral cortical neurons. In addition, the cytotoxic action of lindane as well as a protection by GABA and flunitrazepam were studied together with the ability of lindane to increase the intracellular concentration of free Ca2+. Lindane was found to be toxic to the neurons, an effect that could be completely prevented by the… CONTINUE READING
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