Lincomycin resistance gene lnu(D) in Streptococcus uberis.

  title={Lincomycin resistance gene lnu(D) in Streptococcus uberis.},
  author={Efthymia Petinaki and V{\'e}ronique Gu{\'e}rin-Faubl{\'e}e and Vianney Pichereau and Corinne Villers and Adeline Achard and Brigitte Malbruny and Roland Leclercq},
  journal={Antimicrobial agents and chemotherapy},
  volume={52 2},
Streptococcus uberis UCN 42, isolated from a case of bovine mastitis, was intermediately resistant to lincomycin (MIC = 2 microg/ml) while remaining susceptible to clindamycin (MIC = 0.06 microg/ml) and erythromycin. A 1.1-kb SacI fragment was cloned from S. uberis UCN 42 total DNA on plasmid pUC 18 and introduced into Escherichia coli AG100A, where it conferred resistance to both clindamycin and lincomycin. The sequence analysis of the fragment showed the presence of a new gene, named lnu(D… CONTINUE READING


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