Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation.

Abstract

Based on the report that the introduction of the biosynthetic precursor of lincomycin, propylproline, could increase the production of lincomycin (Bruce et al. in US Patent 3,753,859, 1973), a mutant strain pro10-20, with resistance of feedback suppression of proline (an analog of propylproline) was thus selected and lincomycin production increased by 10… (More)
DOI: 10.1007/s00449-008-0272-y

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Cite this paper

@article{Ye2009LincomycinRS, title={Lincomycin, rational selection of high producing strain and improved fermentation by amino acids supplementation.}, author={Ruifang Ye and Qian Wang and Xiaofang Zhou}, journal={Bioprocess and biosystems engineering}, year={2009}, volume={32 4}, pages={521-9} }