LincRNA-p21 suppresses target mRNA translation.

Abstract

Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability. Under reduced… (More)
DOI: 10.1016/j.molcel.2012.06.027

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@article{Yoon2012LincRNAp21ST, title={LincRNA-p21 suppresses target mRNA translation.}, author={Je-Hyun Yoon and Kotb Abdelmohsen and Subramanya Srikantan and Xiaoling Yang and Jennifer L Martindale and Supriyo De and Maite Huarte and Ming Zhan and Kevin G. Becker and Myriam Gorospe}, journal={Molecular cell}, year={2012}, volume={47 4}, pages={648-55} }