LincRNA-p21 suppresses target mRNA translation.

@article{Yoon2012LincRNAp21ST,
  title={LincRNA-p21 suppresses target mRNA translation.},
  author={Je-Hyun Yoon and Kotb Abdelmohsen and Subramanya Srikantan and Xiaoling Yang and Jennifer L. Martindale and Supriyo De and Maite Huarte and Ming Zhan and Kevin G. Becker and Myriam Gorospe},
  journal={Molecular cell},
  year={2012},
  volume={47 4},
  pages={648-55}
}
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability. Under reduced HuR levels, lincRNA-p21 accumulated in human cervical carcinoma HeLa cells, increasing its association with JUNB and CTNNB1 mRNAs and… CONTINUE READING
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