Linc00423 as a tumor suppressor in retroperitoneal liposarcoma via activing MAPK signaling pathway through destabilizing of NFATC3

@article{Zhang2019Linc00423AA,
  title={Linc00423 as a tumor suppressor in retroperitoneal liposarcoma via activing MAPK signaling pathway through destabilizing of NFATC3},
  author={Yong Zhang and Hanxing Tong and Junyi He and Yebo Shao and Xi Guo and Rongyuan Zhuang and Jue Quin Yang and Ju Liu and Yuqin Ding and Wenshuai Liu and Wei-qi Lu and Yuhong Zhou},
  journal={Cell Death \& Disease},
  year={2019},
  volume={10}
}
Unraveling the noncoding RNA expression networks governing cancer initiation and development is essential while remains largely uncompleted in retroperitoneal liposarcoma (RLS). Through RNA-seq technologies and computational biology, deregulated long noncoding RNAs (lncRNAs) are being identified and reveal that lncRNAs are implicated in serial steps of RLS development. High-throughput sequencing with computational methods for assembling the transcriptome of five paired RLS patient’s tissues. We… 
1 Citations
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This study demonstrated that m6A-related lncRNAs were significantly associated with prognosis and tumor immune microenvironment and could function as independent prognosis-specific predictors in STS, thereby providing novel insights into the roles of m6-methylandenosine-related long non-coding RNAs in STs.

References

SHOWING 1-10 OF 55 REFERENCES
A novel long noncoding RNA PILRLS promote proliferation through TCL1A by activing MDM2 in Retroperitoneal liposarcoma
It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in
Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications.
TLDR
This review will focus on lncRNAs involved in lung cancer, the most common cause of cancer-related death in the United States and worldwide, and summarize their various methods of discovery, provide consensus rankings of deregulated lnc RNAs in lung cancers, and describe in detail the limited functional analysis that has been undertaken so far.
Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications
TLDR
This review will focus on lncRNAs involved in lung cancer, the most common cause of cancer-related death in the United States and worldwide, and summarize their various methods of discovery, provide consensus rankings of deregulated lnc RNAs in lung cancers, and describe in detail the limited functional analysis that has been undertaken so far.
The crosstalk between long non-coding RNAs and PI3K in cancer
TLDR
LncRNAs and PI3K have been shown to be interconnected in several different cancer subtypes enhancing aberrant cell proliferation, epithelial-to-mesenchymal transition, migration and invasion, and also cancer cell metabolism.
Analysis of dysregulated long non-coding RNA expressions in glioblastoma cells.
TLDR
Long non coding RNAs showed low expression in glioblastoma compared to the human (parental) brain cancer stem cells, indicating their role as tumour suppressor genes on gliomas.
HOTAIR: a key regulator in gynecologic cancers
TLDR
This review summarizes the recent findings on the roles of HOTAIR in gynecologic cancers and describes the underlying mechanisms governing HotaIR function.
Analysis of long non-coding RNA expression profiles identifies novel lncRNA biomarkers in the tumorigenesis and malignant progression of gliomas.
TLDR
Functional analysis suggested that the four lncRNAs associated with survival of patients with GBM may be involved in cancer-related biological processes and pathways and their deregulation may lead to GBM tumorigenesis and progression.
Analysis of long non-coding RNA expression profiles identifies novel lncRNA biomarkers in the tumorigenesis and malignant progression of gliomas
TLDR
Functional analysis suggested that the four lncRNAs associated with survival of patients with GBM may be involved in cancer-related biological processes and pathways and their deregulation may lead to GBM tumorigenesis and progression.
Analysis of Long Non-Coding RNA Expression of Lymphatic Endothelial Cells in Response to Type 2 Diabetes
TLDR
A set of lncRNAs were differentially expressed in lymphatic endothelial cells in response to type 2 diabetes and these lnc RNAs may be involved in the pathogenesis of diabetes-related complications.
FUS–DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma
TLDR
A preclinical study substantiates the fundamental role of the IGF-IR/PI3K/Akt signaling pathway in myxoid liposarcoma pathogenesis and provides a mechanism-based rationale for molecular- targeted approaches in myXoid lipo-cancer therapy.
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