Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis.

@article{Yuan2012Lin28bRA,
  title={Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis.},
  author={Joan Yuan and Cuong K. Nguyen and Xiuhuai Liu and Chrysi Kanellopoulou and Stefan A. Muljo},
  journal={Science},
  year={2012},
  volume={335 6073},
  pages={1195-200}
}
The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or thymus. We demonstrate that ectopic expression of Lin28 reprograms hematopoietic… CONTINUE READING
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S. J. Morrison, H. D. Hemmati, A. M. Wandycz, I. L. Weissman
Natl. Acad. Sci. U.S.A. 92, • 1030

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