Lin28a protects against postinfarction myocardial remodeling and dysfunction through Sirt1 activation and autophagy enhancement.

Abstract

BACKGROUND Myocardial remodeling and cardiac dysfunction prevention may represent a therapeutic approach to reduce mortality in patients with myocardial infarction (MI). We investigated the effects of Lin28a in experimental MI models, as well as the mechanisms underlying these effects. METHODS Left anterior descending (LAD) coronary artery ligation was… (More)
DOI: 10.1016/j.bbrc.2016.09.122

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