Lin28 and let-7 in the Metabolic Physiology of Aging

  title={Lin28 and let-7 in the Metabolic Physiology of Aging},
  author={Elwin Tan Jun-Hao and Renuka Gupta and Ng Shyh-Chang},
  journal={Trends in Endocrinology & Metabolism},
  • Elwin Tan Jun-Hao, Renuka Gupta, Ng Shyh-Chang
  • Published 2016
  • Medicine, Biology
  • Trends in Endocrinology & Metabolism
  • The Lin28/let-7 molecular switch has emerged as a central regulator of growth signaling pathways and metabolic enzymes. Initially discovered to regulate developmental timing in the nematode, the Lin28/let-7 pathway of RNA regulation has gained prominence for its role in mammalian stem cells, cancer cells, tissue development, and aging. By regulating RNAs, the pathway coordinates cellular growth and cellular metabolism to influence metabolic physiology. Here, we review this regulatory mechanism… CONTINUE READING
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